Chronic Stress influence on Cancer
المسار: Education
I would like to do a research on how Chronic Stress influence on Cancer Genetically. Chronic Stress Activates Hormonal Responses • Chronic stress triggers the hypothalamic-pituitary-adrenal (HPA) axis. • This leads to increased cortisol (the “stress hormone”) and other stress hormones like adrenaline. • Impact: High cortisol over time suppresses immune surveillance — your body’s ability to detect and destroy abnormal cells decreases. Stress Leads to Chronic Inflammation • Stress hormones can increase pro-inflammatory molecules (like cytokines). • Chronic inflammation creates an environment that promotes DNA damage and cell proliferation. • Impact: Mutated cells are more likely to survive and multiply instead of being eliminated. Epigenetic Modifications • Chronic stress can change how genes are expressed without altering the DNA sequence. • Mechanisms include: o DNA methylation → silences tumor suppressor genes (e.g., TP53, BRCA1) o Histone modification → changes how DNA is packaged, affecting gene activity • Impact: Genes that normally prevent cancer may be “turned off,” increasing vulnerability. DNA Damage and Impaired Repair • Stress can interfere with DNA repair mechanisms, meaning mutations accumulate faster. • Cells with damaged DNA that aren’t repaired can transform into cancerous cells. • Impact: Genetic instability in breast tissue increases cancer risk. Interaction with Genetic Susceptibility • People with BRCA1/2 mutations or other cancer-related genes are more sensitive to these mechanisms.
#Chronic_Stress Activates Hormonal Responses#Stress_Leads to Chronic Inflammation#Epigenetic_Modifications#DNA_Damage and Impaired Repair#Interaction_with Genetic Susceptibility
